Research Projects

AOECS has participated in several EU-funded research projects, looking into various aspects of coeliac disease such as the development of a less invasive diagnostic tool as well as evaluations of diagnosis guidelines for children.


The objective of this EU-funded project was to obtain an instrument that will be a low-cost non-invasive intelligent diagnosis system that can be present at point of care, such as a doctor’s surgery which will bring benefits to patients and healthcare professionals.

The applications of the proposed integrated micro system and its individual modules for coeliac disease diagnosis, monitoring and management are multiple. The analysis of the HLA-DQ2 & 8 genes will provide information on the genetic predisposition of an individual, while serum IgA and IgG indicate antibodies associated with gluten in the diet.

For more information, please visit the CD-Medics webpage


The project was a European multicentre study funded by a grant from the European Union (FP6-2005-FOOD-4B-36383). The study involved 17 partners of 11 countries: 13 clinical centres, 3 industrial companies and AOECS, the representative of coeliac patients.

The study investigated the influence of infant feeding on the risk of developing CD. The hypothesis is that by exposing infants to small quantities of gluten while they are still being breast-fed to possibly induce tolerance to gluten thus reducing the risk for CD in genetically susceptible individuals.

For more information, please visit the Prevent CD website.


The acronym stands for Prospective Celiac Disease Diagnostic Evaluation.

The reference standard for the diagnosis of Celiac Disease (CD) is based on estimates using mostly retrospective evaluations or data from single-center studies. Therefore, the working group of ESPGHAN on the diagnostic criteria of CD felt obliged to evaluate the new criteria on a large pediatric population in different countries and settings including a broad range of symptomatic and asymptomatic children which are referred for further work up because of a positive test result for antibodies against tissue transglutaminase. The ProCeDE study aims to provide prospective data to assure that this diagnostic procedure is valid also in clinical practice with positive predictive value above 99%. Furthermore, interobserver variability for histology and inter-test variability will be assessed and the impact of HLA-typing on diagnosis will be evaluated.

For more information, please read the project summary.