Our collection of research that may be useful knowledge to you
Research projects in the area of coeliac disease have increased significantly in the last ten years, largely thanks to the efforts of our larger and more established Member societies. Medical experts in the fields of gastroenterology, immunology and genetics have been funded to research various aspects of coeliac disease, such as less invasive diagnosis, treatment or cure and psychological and economic burden on coeliac patients.
The objective of this EU-funded project was to obtain an instrument that will be a low-cost non-invasive intelligent diagnosis system that can be present at point of care, such as a doctor’s surgery which will bring benefits to patients and healthcare professionals.
The applications of the proposed integrated micro system and its individual modules for coeliac disease diagnosis, monitoring and management are multiple. The analysis of the HLA-DQ2 & 8 genes will provide information on the genetic predisposition of an individual, while serum IgA and IgG indicate antibodies associated with gluten in the diet.
The project was a European multicentre study funded by a grant from the European Union (FP6-2005-FOOD-4B-36383). The study involved 17 partners of 11 countries: 13 clinical centres, 3 industrial companies and AOECS, the representative of coeliac patients.
The study investigated the influence of infant feeding on the risk of developing CD. The hypothesis is that by exposing infants to small quantities of gluten while they are still being breast-fed to possibly induce tolerance to gluten thus reducing the risk for CD in genetically susceptible individuals.
Prospective Celiac Disease Diagnostic Evaluation.
The reference standard for the diagnosis of Celiac Disease (CD) is based on estimates using mostly retrospective evaluations or data from single-center studies. Therefore, the working group of ESPGHAN on the diagnostic criteria of CD felt obliged to evaluate the new criteria on a large paediatric population in different countries and settings including a broad range of symptomatic and asymptomatic children which are referred for further work up because of a positive test result for antibodies against tissue transglutaminase. The ProCeDE study aims to provide prospective data to assure that this diagnostic procedure is valid also in clinical practice with positive predictive value above 99%. Furthermore, interobserver variability for histology and inter-test variability will be assessed and the impact of HLA-typing on diagnosis will be evaluated.
MEASURING GLUTEN IN FOOD
This is an article titled Determination of Gliadin as a Measure of Gluten in Food by R5 sandwich ELISA RIDASCREEN®
Background: According to Codex Alimentarius, food products containing less than 20 mg/kg gluten, can be labeled as "gluten-free". Since 2002, the R5 antibody method allowed the determination of gluten levels and led to a huge improvement of products available to CD patients.
The National Center for Biotechnology Information (NCBI) is an excellent source for research papers on coeliac disease and other associated conditions.